Finasteride Gel in the Treatment of Male Pattern Baldness

Finasterde is the sole active substance of Propecia, the only clinically proven pill approved for the treatment of male pattern baldness. Finasteride is widely known and available as generic Propecia. Finasteride, a selective 5a-reductase inhibitor, is reducing the dihydroxytestestrone (DHT) levels in the human body and is, therefore, essential in the treatment of male androgenic alopecia.

The aim of a recently conducted study with finasteride was to compare the topical and oral finasteride in the treatment of androgenic alopecia. In this double blind, randomized, clinical trial study 45 male hair loss patients have participated. Patients with male androgenic alopecia were selected according to their hair loss history and physical examinations. The patients were randomly divided in two test groups - the one that was using the topical finasteride and the second group of patients who used oral finasteride. The topical finasteride group of patients received a topical gel containing 1% of finasteride and placebo tablets, while the oral finasteride group received finasteride tablets (1 mg) and gel base (without any active substance) as placebo for 6 months. The patients have undergone clinical observation and recording of side effects prior to the treatment and at the end of the first week and then by a monthly follow-up. The size of the bald area, the total hair count and the number of terminal hairs were studied. The data were analyzed by descriptive and Chi-square statistical test. The mean duration of hair loss in the studied subjects was ca two years. Each month the terminal hair, size of the bald area and hair count between the two groups were compared.

The results have shown that there were no significant differences between the two test groups in terms of hair thickness, hair counts and the size of the balding area. Serial measurements have indicated a significant increase in terminal hair counts in both groups. Therefore, it can be concluded that the therapeutic effects of both, the topical finasteride gel and the oral finasteride tablet were about the same.

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